Figure 1613

FIGURE 16-12 (Continued)

B-D, Moreover, indirect immunofluorescence with antithyroglobulin antibody demonstrates that the nonsecreted protein is trapped almost entirely in the ER. Together with data from Northern blot analysis, this suggests that perturbation of ER function and disruption of the secretory pathway is likely to be a key cellular lesion in ischemia [11]. MED—control media; PBS—phos-phate-buffered saline. (From Kuznetsov et al. [11]; with permission.)

Antimycin A MED PBS 1 5 10

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