Figure 1615

Results of 4 years of experience monitoring outcomes by the North American Pediatric Renal Transplant Cooperative Study. These results suggest a statistically significant beneficial effect of donor-related matching (P < 0.05) when analyzing this allele with other effects unique to pediatric patients with regard to age. This figure displays the subgroup with a match at both the A and the B locus, or at neither, and compares that with the effect of adding a donor-related (DR) antigen on the percentage of renal allografts surviving after transplantation. Owing to the relatively short follow-up, small sample size (1558 patients), and nonimmunologic factors pertinent to pediatric transplantation, it is difficult to determine separate time-varying effects of class I versus class II matching. However, it does seem clear that no antigen matching has a worse prognosis at 1 year (72% graft survival) versus 1 or more antigen matching at each locus (1-year 81% survival, 2-year 69% survival). (From McEnery and Stablein [11]; with permission.)

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