Figure 1617

Motogenic effect of growth factors—hepatocyte growth factor (HGF) induces cell "scattering." During development or regeneration the recruitment of cells to areas of new growth is vital. Growth factors have the ability to induce cell movement. Here, subconfluent monolayers of either Madin-Darby canine kidney (MDCK) C, D, or murine inner medullary collecting duct (mIMCD) A, B, cells were grown for 24 hours in the absence, A, C, or presence B, D, of 20 ng/mL HGF. Treatment of either type of cultured renal epithelial cell with HGF induced the dissociation of islands of cells into individual cells. This phenomenon is referred to as scattering. HGF was originally identified as scatter factor, based on its ability to induce the scattering of MDCK cells [83]. Now, it is known that HGF and its receptor, the transmembrane tyrosine kinase c-met, play important roles in development, regeneration, and carcinogenesis [83]. (From Cantley et al. [84]; with permission.)

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