Figure 1623

Mechanism of growth factor action. Proposed model for the generalized response of epithelial cells to growth factors, which the depends on their environment. Epithelial cells constantly monitor their surrounding environment via extracellular receptors (ie, inte-grin receptors) and respond accordingly to growth factor stimulation. If the cells are in the appropriate environment, growth factor binding induces cellular responses necessary for branching tubulo-genesis. There are increases in the levels of extracellular proteinases and of structural and functional changes in the cytoarchitecture that enable the cells to form branching tubule structures.

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