Figure 1629

Analysis of the safety and efficacy of growth hormone in pediatric renal transplantation recipients. Overall, a catch-up in growth was reported in each study, with changes in height standard deviation score from 0.2 to 1.0. These results were not as favorable as those reported when growth hormone was used in patients with chronic renal failure, perhaps owing to the use of corticosteroids after transplantation. In three studies, renal function was significantly decreased after administration of growth hormone. Twelve acute rejection episodes and four graft losses occurred; however, a causal relationship is unclear [30]. A controlled trial using growth hormone after transplantation is currently underway by the North American Pediatric Renal Transplant Cooperative Study to help establish the efficacy and safety of growth hormone in pediatric transplantation recipients. Calculated clearance according to the Schwartz formula, except for Tonshoff (inulin clearance) [31]. (From Tonshoff [31]; with permission.)

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