Figure 1630

When impaired graft function occurs in pediatric renal transplantation recipients, rejection is the most common cause. A number of other conditions exist that also can result in an increase in serum creatinine and blood urea nitrogen, a decrease in urine output, or both, which must be differentiated from rejection. In small children with large allografts, the most sensitive indication of rejection is hypertension. It is important to remember that in small children, a small increase in serum creatinine can reflect a significant decrease in the glomerular filtration rate. Several methods to establish the cause of renal allograft dysfunction are described; however, the diagnostic gold standard is the allograft core biopsy. Biopsy can easily be performed percutaneously in most children and should not be postponed once other variables have been eliminated and rejection is likely. (From Yadin and coworkers [32]; with permission.)

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Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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