Figure 1638

Recurrence rates and graft failure from recurrent disease. Some primary renal diseases may recur in the allograft, making the underlying disease an important consideration when evaluating a child for renal transplantation. Focal segmental glomerular sclerosis and atypical hemolytic uremic syndrome recur in roughly 25% of cases. These diseases are severe clinically and lead to the highest percentage of graft failures, ie, 40% to 50%. In contrast, membra-noproliferative glomerulonephritis type II recurs in all cases; however, it is not very severe clinically and leads to graft failure in only 10% to 20% of patients. FSGS—focal segmental glomerulosclerosis; HSP— Henoch-Schonlein purpura; HUS—hemolyt-ic-uremic syndrome; MPGN—membra-noproliferative glomerulonephritis; SLE— systemic lupus erythematosus. (From Fine and Ettenger [37]; with permission.)

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