Figure 1717

Body weights of rats with ischemic acute renal failure (ARF) treated with insulin-like growth factor (IGF-I) or vehicle. Unlike epidermal growth factor or hepatocyte growth factor (HGF), IGF-I is anabolic even in the setting of acute renal injury. These data are from the experiment described in Figure 17-16. As the data in this figure demonstrate, ARF is a highly catabolic state: vehicle-treated animals experience 15% weight reduction. Animals that received IGF-I experienced only a 5% reduction in body weight and were back to baseline by 7 days. Data are expressed as mean ± standard error. Significant differences between groups are indicated by asterisks. (From Miller et al. [2]; with permission.)

0 0

Post a comment