Figure 172

Growth regulation after an acute insult in regenerating renal tubule epithelial cells. Under the influence of growth-stimulating factors the damaged renal tubule epithelium is capable of regenerating with restoration of tubule integrity and function. The growth factors may be 1) produced by the tubule epithelium itself and act locally in an autocrine, juxtacrine or paracrine manner; 2) produced by surrounding cells to work in a paracrine manner; or 3) presented to the regenerating area via the circulation mediated by an endocrine mechanism. Cells at the edge of an injured nephron segment are illustrated on the left. These cells proliferate in response to the growth-stimulating factors. The middle cell is in the process of dividing and the cell on the right is migrating into the area of injury. (Adapted from Toback [1]; with permission.)

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