Figure 1723

Limitations in the use of growth factors to treat acute renal failure (ARF). The disappointing results of several recent clinical trials of ARF therapy reflect the fact that our understanding of its pathophysi-ology is still limited. Screening compounds using animal models may be irrelevant. Most laboratories use relatively young animals, even though ARF frequently affects older humans, whose organ regenerative capacity may be limited. In addition, our laboratory models are usually based on a single insult, whereas many of our patients suffer repeated or multiple insults. Until we gain a better understanding of the basic pathogenic mechanisms of ARF, studies in human patients are likely to be frustrating.

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