Figure 176

Receptor binding for epidermal growth factor (EGF). EGF binding in kidney under basal conditions is extensive. The most significant specific binding occurs in the proximal convoluted (PCT) and proximal straight tubules. There is also significant EGF binding in the glomeruli (GLOM), distal convoluted tubules (DCT), and the entire collecting duct (OMCD, IMCD). After an ischemic renal insult, EGF receptor numbers increase. This change in the renal EGF system may be responsible for the beneficial effect of exoge-nously administered EGF is the setting of acute renal failure. CTAL—cortical thick ascending loop.

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