Figure 178

Expression of mRNA for insulin-like growth factor I (IGF-I). Under basal conditions, a variety of nephron segments can produce IGF-I. Glomeruli (GLOM), medullary and cortical thick ascending limbs (MTAL/CTAL), and collecting ducts (OMCD, IMCD) are all reported to produce IGF-I. Within hours of an acute ischemic renal insult, the expression of IGF-I decreases; however, 2 to 3 days after the insult, when there is intense regeneration, there is an increase in the expression of IGF-I in the regenerative cells. In addition, extratubule cells, predominantly macrophages, express IGF-I in the regenerative period. This suggests that IGF-I works by both autocrine and paracrine mechanisms during the regenerative process. DCT/PCT—distal/proximal convoluted tubule.

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