Figure 179

Receptor binding for insulin-like growth factor I (IGF-I). IGF-I binding sites are conspicuous throughout the normal kidney. Binding is higher in the structures of the inner medulla than in the cortex. After an acute ischemic insult, there is a marked increase in IGF-I binding throughout the kidney. The increase appears to be greatest in the regenerative zones, which include structures of the cortex and outer medulla. These findings suggest an important trophic effect of IGF-I in the setting of acute renal injury. CTAL/MTAL—cortical/medullary thick ascending loop; DCT/PCT—distal/proximal convoluted tubule; GLOM—glomerulus; OMCD/IMCD—outer/inner medullary collecting duct.

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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