Figure 179

Receptor binding for insulin-like growth factor I (IGF-I). IGF-I binding sites are conspicuous throughout the normal kidney. Binding is higher in the structures of the inner medulla than in the cortex. After an acute ischemic insult, there is a marked increase in IGF-I binding throughout the kidney. The increase appears to be greatest in the regenerative zones, which include structures of the cortex and outer medulla. These findings suggest an important trophic effect of IGF-I in the setting of acute renal injury. CTAL/MTAL—cortical/medullary thick ascending loop; DCT/PCT—distal/proximal convoluted tubule; GLOM—glomerulus; OMCD/IMCD—outer/inner medullary collecting duct.

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