Figure 1823

Micronutrients in acute renal failure (ARF): antioxidative factors. Micronutrients are part of the organism's defense mechanisms against oxygen free radical induced injury to cellular components. In experimental ARF, antioxidant deficiency of the organism (decreased vitamin E or selenium status) exacerbates ischemic renal injury, worsens the course, and increases mortality, whereas repletion of antioxidant status exerts the opposite effect [45]. These data argue for a crucial role of reactive oxygen species and peroxidation of lipid membrane components in initiating and mediating ischemia or reperfusion injury.

In patients with multiple organ dysfunction syndrome and associated ARF (lightly shaded bars) various factors of the oxygen radical scavenger system are profoundly depressed as compared with healthy subjects (black bars): plasma concentrations of vitamin C, of ^-carotene, vitamin E, selenium, and glutathione all are profoundly depressed, whereas the end-product of lipid peroxidation, malondialdehyde, is increased (double asterisk, P < 0.01; triple asterisk, P < 0.001). This underlines the importance of supplementation of antioxidant micronutrients for patients with ARF. (Adapted from Druml et al. [46]; with permission.)

0 0

Post a comment