Figure 212

All of the small vessel vasculitides share signs and symptoms of small vessel injury in multiple different tissues; however, the frequency of involvement varies among the different diseases [1]. Combined renal and pulmonary involvement (pulmonary-renal syndrome) is most common in ANCA vasculitis, whereas combined renal and dermal involvement (dermal-renal syndrome) is most common in immune complex vasculitis. The cutaneous involvement in small vessel vasculitides usu ally manifests as purpura caused by venulitis, but occasionally is more nodular or necrotizing secondary to arteritis or granulomatous inflammation. Nodular cutaneous lesions, as well as neuropathies, abdominal pain, and musculoskeletal symptoms also can be caused by medium sized vessel vasculitis (eg, polyarteritis nodosa), and thus these clinical manifestations are not specific for a small vessel vasculitis; whereas glomerulonephritis, purpura, or alveolar capillaritis are.

0 0

Post a comment