Figure 212

Mechanism of atrial natriuretic peptide (ANP) action on the kidney. Animals with disruption of the particulate form of guanylyl cyclase (GC) manifest increased mean arterial pressure that is independent of dietary intake of sodium chloride. To test whether ANP mediates its renal effects by way of the action of GC, ANP was infused into wild-type and GC-A-deficient mice. In wild-type animals, ANP led to prompt natriuresis. In GC-A-deficient mice, no effect was observed. UNaV—urinary sodium excretion volume. (Modified from Kishimoto [24].)

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Afferent Efferent

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