Figure 22

Age-associated prevalence of various glomerular lesions in nephrotic syndrome. This schematic illustrates the age-associated prevalence of various diseases and glomerular lesions among children and adults undergoing renal biopsy for evaluation of nephrotic syndrome (Guy's Hospital and the International Study of Kidney Disease in Children) [1]. Both the systemic and primary causes of nephrotic syndrome are included. (Diabetes mellitus with nephropathy is underrepresented because renal biopsy is seldom needed for diagnosis.) The bar on the left summarizes the prevalence of various lesions in children aged 0 to 16 years; the bar on the right summarizes the prevalence of various lesions in adults aged 16 to 80 years. Note the high prevalence of minimal change disease in children and the increasing prevalence of membranous glomeru-lonephritis in the age group of 16 to 60 years. FSGS—focal segmental glomeru-osclerosis; MCGN—mesangiocapillary glomerulonephritis. (From Cameron [1]; with permission.)

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