Figure 238

Sites of sodium (Na) reabsorption along the nephron in control and nephrotic rats (induced by puromycin aminonucleoside [PAN]). The glomerular filtration rates (GFR) in normal and nephrotic rats are shown by the hatched bars. Note the modest reduction in GFR in the nephrotic group, a finding that is common in human nephrosis. Fractional reabsorption rates along the proximal tubule, the loop of Henle, and the superficial distal tubule are indicated. The fractional reabsorption along the collecting duct (CD) is estimated from the difference between the end distal and urine deliveries. The data suggest that the predominant site of increased reabsorption is the collecting duct. Because superficial and deep nephrons may differ in reabsorptive rates, these data would also be consistent with enhanced reabsorption by deep nephrons. Asterisk—data inferred from the difference between distal and urine samples. (Data from Ichikawa and coworkers [72].)

Fluid intake

Nonrenal fluid loss i

Net volume intake

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