Figure 24

The two major categories of large vessel vasculitis, giant cell (temporal) arteritis and Takayasu arteritis, are both characterized pathologically by granulomatous inflammation of the aorta, its major branches, or both. The most reliable criterion for distinguishing between these two disease is the younger age of patients with Takayasu arteritis compared with giant cell arteritis [3]. The presence of polymyalgia rheumatica supports a diagnosis of giant cell arteritis. Clinically significant renal disease is more commonly associated with Takayasu arteritis than giant cell arteritis, although pathologic involvement of the kidneys is a frequent finding with both conditions [4,5].

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