Schematic of basement membrane collagen type IV. The postulated arrangement of type IV collagen chains in a normal glomerular basement membrane is illustrated. The joining of noncollagen (NC-1) and 75 domains creates a lattice (chicken wire) arrangement (A). In the glomerular basement membrane, a1 and a2 chains predominate in the triple helix (B), but a3, 4, 5, and 6 chains are also found (not shown). Disruption of synthesis of any of these chains may lead to anatomic and pathologic alternations, such as those seen in Alport's syndrome. Arrows indicate fibrils. (From Abrahamson and coworkers [1]; with permission.)

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