Figure 34

Systemic amyloidosis. Types of proteins constituting the amyloid of ^-microglobulin. The amyloid fibrils consist of mutated transthyretin fibrils. In primary amyloidosis the fibrils consist of monoclonal k or X or, rarely, fibrinogen a or lysozyme in familial amyloidosis. Senile light chains. In secondary amyloidosis the fibrils consist of protein A. systemic amyloidosis is characterized by the deposition of normal

Systemic amyloidosis associated with long-term hemodialysis consists transthyretin in the heart. (From Kyle and Gertz [5]; with permission.)

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