Figure 346

Wide geographic distribution of familial amyloidosis. Familial or hereditary amyloidosis has an autosomal dominant pattern of inheritance. It accounts for 3.5% of our cases of amyloidosis. In our practice, the geographic distribution is wide and not associated with clustering. Frequently, a family history of amyloidosis was not obtained until after amyloidosis was diagnosed [17]. More than 50 transthyretin mutations have been recognized [18]. (Adapted from Gertz et al. [17]; with permission.)

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