Figure 413

A-E, Relationship between concentrating capacity and patient age. Over a prolonged period, we investigated the effect of multiple transfusions of hemoglobin A erythro-cytes into children and adults with sickle cell anemia (4, 7, 11, 15, and 40 years). In the first panel, the effects of multiple transfusions of normal blood given to a 4-year-old boy with homozygotic sickle cell anemia. A significant improvement in concentrating capacity can be observed. This diminishes in older patients.

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