Histology of the adrenal. A cross section of the normal adrenal before (¡eft) and after (right) stimulation with adrenocorticotropic hormone (ACTH) . The adrenal is organized into the outer adrenal cortex and the inner adrenal medulla. The outer adrenal cortex is composed of the zona glomerulosa, zona fasciculata, and zona reticularis. The zona glomerulosa is responsible for production of aldosterone and other mineralocorticoids and is chiefly under the control of angiotensin II (see Figs. 4-3 and 4-5). The zona fasciculata and zona reticularis are influenced primarily by ACTH and produce glucocorticoids and some androgens (see Figs. 4-3 and 4-19). The adrenal medulla produces catecholamines and is the major source of epinephrine (in addition to the organ of Zuckerkandl located at the aortic bifurcation) (see Fig. 4-25.)
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