Figure 425

Synthesis, actions, and metabolism of catecholamines. Depicted is the synthesis of catecholamines in the adrenal medulla [9]. Epinephrine is only produced in the adrenal and the organ of Zuckerkandl at the aortic bifurcation. Norepinephrine and dopamine can be produced and released at all other parts of the sympathetic nervous system. The kidney is the primary site of excretion of catecholamines and their metabolites, as noted here. The kidney also can contribute catecholamines to the urine. The relative contributions of norepinephrine and epinephrine to biologic events is noted by the plus signs. BMR—basal metabolic rate; CNS—central nervous system; NEFA—nonesterified fatty acids; VMA—vanillylmandelic acid.

0 0

Post a comment