Figure 513

Glomerular filtration of calcium (Ca). Total serum Ca consists of ionized, protein bound, and complexed fractions (47.5%, 46.0%, and 6.5%, respectively). The complexed Ca is bound to molecules such as phosphate and citrate. The ultrafilterable Ca equals the total of the ionized and complexed fractions. Normal total serum Ca is approximately 8.9 to 10.1 mg/dL (about 2.2-2.5 mmol/L). Ca can be bound to albumin and globulins. For each 1.0 gm/dL decrease in serum albumin, total serum Ca decreases by 0.8 mg/dL; for each 1.0 gm/dL decrease in serum globulin fraction, total serum Ca decreases by 0.12 mg/dL. Ionized Ca is also affected by pH. For every 0.1 change in pH, ionized Ca changes by 0.12 mg/dL. Alkalosis decreases the ionized Ca [1,6,7].

| | Parathyroid hormone and 1,25(OH)2D3 I I Calcitonin I | Thiazides

Ca2+ ATPase, VDR, CaBP-D, Na+/Ca2+ exchanger colocalized here

| | Parathyroid hormone and 1,25(OH)2D3 I I Calcitonin I | Thiazides

Ca2+ ATPase, VDR, CaBP-D, Na+/Ca2+ exchanger colocalized here

0 0

Post a comment