Figure 517

Use of ciglitazone to abolish calcium concentration elevation. Ciglitazone, a thiazolidinedione, abolishes agonist-stimulated sustained elevations of intracellular calcium concentrations. Shown are time-dependent plots of changes in intracellular calcium (in arbitrary units; [Ca2+]j) induced by platelet-derived growth factor (PDGF) in human gliobastoma cells with and without preincubation with ciglitazone. A, Addition of PDGF to control cells is indicated by the vertical line. B, An identical experiment conducted on cells pretreated with ciglitazone. The capacity of this agent to shorten the duration of agonist-stimulated increases in intracellular calcium may result in attenuation of both growth of vascular smooth muscle cells and vasoconstriction. (From Pershadsingh and coworkers [14]; with permission.)




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