Figure 519

Effect of pioglitazone on insulin-induced proliferation of arterial smooth muscle cells. Inhibition of insulin-stimulated vascular hyperplasia and hypertrophy is one potential mechanism by which insulin-sensitizing and lipid-lowering agents may decrease peripheral resistance. Two kinds of evidence suggest that thiazolidinediones inhibit the growth of vascular smooth muscle cells in vitro. Shown here, pioglitazone inhibits insulin-stimulated proliferation of vascular smooth muscle cells. Pioglitazone also inhibits 3H-thymidine incorporation in vascular smooth muscle cells (Fig. 5-19). FCS—fetal calf serum. (From Dubey and coworkers [11]; with permission.)

• Insulin = 1 mU/mL o EGF = 100 mg/mL ▼ 5% FCS T
Supplements For Diabetics

Supplements For Diabetics

All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.

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