Figure 519

Causes of hematuria and/or the nephrotic syndrome. Hematuria and/or the nephrotic syndrome may occur in association with malignancy without causing acute or chronic renal failure. Causes may include one of the many paraneoplastic types of glomerulonephritis, with proteinuria and often the nephrotic syndrome resulting from the glomerular injury; hematuria is also noted in some cases. In contrast, isolated hematuria is the predominant feature when primary or metastatic renal cancer erodes the intrarenal vasculature. Proteinuria, and in some cases the nephrotic syndrome, may be the presenting nephrotoxicity of cancer chemotherapy agents.

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