Figure 520

Effect of pioglitazone on 3H-thymidine incorporation in vascular smooth muscle cells. 3H-thymidine incorporation is stimulated by insulin, fetal calf serum (FCS), and epidermal growth factor (EGF). Pioglitazone inhibits 3H-thymidine incorporation stimulated by each of these mitogens. Similar observations have been made with pravastatin and lovastatin. (From Dubey and coworkers [11]; with permission.)

Norepinephrine, Angiotensin II, ng/kg/min ng/kg/min

Norepinephrine, Angiotensin II, ng/kg/min ng/kg/min

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