Figure 524

Half-maximal values for acetylcholine-induced vasodilation in aortic strips prein-cubated with insulin, pioglitazone, or both. In the presence of insulin, pioglitazone augments endothelium-dependent vasodilation. In vitro, the half-maximal values for acetylcholine-induced vasodilation is less in aortic strips incubated with insulin plus pioglitazone (ie, the strips are more responsive to acetylcholine) than in control strips or strips incubated with insulin alone or pioglitazone alone [16].

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