Figure 525

Effect of clofibrate on 20-hydroxy-eicosate-traenoic (20-HETE) production in Dahlsalt-sensitive rats. Insulin stimulates sodium reabsorption in the proximal tubule. Consequently, lowering plasma insulin concentrations by increasing insulin sensitivity would potentially result in less sodium retention. In addition, clofibrate induces renal P-450 fatty acid w-hydroxylase activity and, hence, increases metabolism of arachi-donic acid to 20-HETE. (From Roman and coworkers [12]; with permission.)

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