Parathyroid-hormone-related protein (PTHrP). PTHrP was initially described as the causative circulating factor in the humoral hypercalcemia of malignancy, particularly in breast cancer, squamous cell cancers of the lung, renal cell cancer, and other tumors. It is now clear that PTHrP can be expressed not only in cancer but also in many normal tissues. It may play an important role in the regulation of smooth muscle tone, transepithelial Ca transport (eg, in the mammary gland), and the differentiation of tissue and organ development [7,13]. Note the high degree of homology between PTHrP and PTH at the amino end of the polypeptides. MW—molecular weight; N—amino terminal; C—carboxy terminal. (From Root [7]; with permission.)

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