Figure 61

Diagram of the approximate relative volume composition of tissue compartments at different segments of the kidney in rats. The interstitium of the kidney consists of peritubular and periarterial spaces. The relative contribution of each of these two spaces to interstitial volume varies, reflecting in part the arbitrary boundaries used in assessing them, but increases in size from the cortex to the papilla. In the cortex there is little interstitium because the peritubular capillaries occupy most of the space between the tubules. The cortical interstitial cells are scattered and relatively inconspicuous. In fact, a loss of the normally very close approximation of the cortical tubules is the first evidence of TIN. In the medulla there is a noticeable increase in interstitial space. The interstitial cells, which are in greater evidence, have characteristic structural features and an organized arrangement. The ground substance of the renal interstitium contains different types of fibrils and basementlike material embedded in a glycosaminoglycan-rich substance. (From Bohman [1]; with permission.)

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