Figure 610

The infiltrating interstitial cells contribute to the course TIN. However, increasing evidence exists for a primary role of the tubular epithelial cells in the recruitment of interstitial infiltrating cells and in perpetuation of the process. Injured epithelial cells secrete a variety of cytokines that have both chemoattractant and pro-inflammatory properties. These cells express a number of cell surface markers that enable them to interact with infiltrating cells. Injured epithelial cells also participate in the deposition of increased interstitial matrix and fibrous tissue. Listed are cytokines, cell surface markers, and matrix components secreted by the renal tubular cell that may play a role in the development of tubulointerstitial disease.

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