Figure 616

Signs and symptoms of metabolic acidosis. Among the various clinical manifestations, particularly pernicious are the effects of severe acidemia (blood pH < 7.20) on the cardiovascular system. Reductions in cardiac output, arterial blood pressure, and hepatic and renal blood flow can occur and life-threatening arrhythmias can develop. Chronic acidemia, as it occurs in untreated renal tubular acidosis and uremic acidosis, can cause calcium dissolution from the bone mineral and consequent skeletal abnormalities.

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