Figure 617

Three calcium channel blockers and their effects in experimental animals. The results of several studies examining the effects of three different dihydropyridine calcium channel blockers on hemodynamics and injury in the uninephrectomized spontaneously hypertensive rat model of progressive glomerular sclerosis are summarized. The three drugs produced graded declines in mean arterial pressure (MAP), with nifedipine causing the greatest and amlodipine the least reduction in systemic pressure. Micropuncture determinations of glomeru-lar capillary hydraulic pressure (Pqc) revealed that only nifedipine and felodipine caused glomerular pressure to decline significantly. These drugs reduced both the protein excretion rate (PROT) and morphologic evidence of glomerular injury (SCLER). The data are consistent with the hypothesis that antihypertensive agents ameliorate renal damage by reducing glomerular pressure and that, for calcium channel blockers, significant reductions in Pqc occur only when drug administration causes a marked decline in systemic pressure. (From Dworkin [25,26]; with permission.)

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