Figure 620

Multifactorial mechanisms for hypertension in clinical renal disease. An increased intravascular volume, owing to decreased renal excretion of sodium and water as the glomerular filtration rate declines, is probably the primary cause. Activation of sympathetic tone and involvement of the renin-angiotensin system, which is inappropriately stimulated in the setting of volume expansion, have been demonstrated in renal failure. Decreased activity of nitric oxide and other vasorelaxants and increased activity of endothelin and other endogenous vasoconstrictors also are probably contributory.

0 0

Post a comment