Figure 622

Erythrocyte knobs in a patient with falciparum malaria [43]. These erythrocyte knobs contain novel proteins, mainly Plasmodium falciparum erythrocyte membrane protein (PfEMP), histidine-rich protein 1, and histidine-rich protein 2, that are synthesized under the influence of the DNA of the parasite [44-46]. These proteins constitute the sticky points (arrows) by which parasitized erythrocytes aggregate and adhere to blood platelets and endothelial cells [47,48]. EN—electron microphotograph. (Magnification X 12,000.)

mononuclear cell infiltration. ATN is seen in 1% to 4% of patients with falciparum malaria and in up to 60% of those with malignant malaria. (Hematoxylin-eosin stain X 200.)

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