Figure 625

Renal tubular acidosis (RTA) defines a group of disorders in which tubular hydrogen ion secretion is impaired out of proportion to any reduction in the glomerular filtration rate. These disorders are characterized by normal anion gap (hyperchloremic) metabolic acidosis. The defects responsible for impaired acidification give rise to three distinct syndromes known as proximal RTA (type 2), classic distal RTA (type 1), and hyperkalemic distal RTA (type 4).

Tm HCO3—maximum reabsorption of bicarbonate; U-B PCO2—difference between partial pressure of carbon dioxide values in urine and arterial blood.

*This syndrome signifies generalized proximal tubule dysfunction and is characterized by impaired reabsorption of glucose, amino acids, phosphate, and urate.

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