Figure 627

Two patient groups in the study of diet in renal disease. The Modification of Diet in Renal Disease (MDRD) study involved two patient groups. The group in which patients had moderate renal dysfunction (glomerular filtration rate [GFR] between 25 and 55 mL/min) was called Study 1. The other group, which included patients who had more severe renal dysfunction (with a GFR between 13 and 24 mL/min) was called Study 2. The effects of the lower blood pressure (BP) target on patients with proteinuria in Studies 1 and 2 are shown. The y-axis divides patients in Studies 1 and 2 into three groups, depending on urinary protein excretion. The x-axis represents the rate of GFR decline. In the subset of patients in the MDRD trial in both Studies 1 and 2 who had massive proteinuria (protein over 3 g/24 h), the lower blood pressure had an especially salutary effect: the decline in GFR was much slower [37].

Renal survival

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