Figure 635

Maintenance of chloride-responsive metabolic alkalosis. Increased renal bicarbonate reabsorption frequently coupled with a reduced glomerular filtration rate are the basic mechanisms that maintain chloride-responsive metabolic alkalosis. These mechanisms have been ascribed to three mediating factors: chloride depletion itself, extracellular fluid (ECF) volume depletion, and potassium depletion. Assigning particular roles to each of these factors is a vexing task. Notwithstanding, here depicted is our current understanding of the participation of each of these factors in the nephronal processes that maintain chloride-responsive metabolic alkalosis [22-24]. In addition to these factors, the secondary hypercapnia of metabolic alkalosis contributes importantly to the maintenance of the prevailing hyperbicarbonatemia [25].

Maintenance of Cl -resistant metabolic alkalosis

Maintenance of Cl -resistant metabolic alkalosis

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