Figure 73

Membranoproliferative glomerulonephritis with hepatitis C. Micrograph of a biopsy showing membranoproliferative glomeru-lonephritis (MPGN) in a patient with hepatitis C virus (HCV) infection. A lobulated glomerulus with mesangial proliferation and an increase in the mesangial matrix are seen. Although still an idiopath-ic disease in many cases, HCV appears to be responsible for some cases of MPGN [13,16]. It has been suggested that the decline in the incidence of idiopathic type 1 MPGN may be partly a result of more careful screening by blood banks, leading to a decrease in the overall incidence of HCV infection and subsequent glomerulonephritis [16].

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