Figure 732

Tubuloreticular cytoplasmic inclusions. Micrograph of tubuloreticular cytoplasmic inclusions in glomerular endothelial cell. The latter are virtually diagnostic of nephropathy associated with HIV infection, provided systemic lupus erythematosus has been excluded. On immunofluo-rescent examination, findings in the glomeruli are nonspecific and similar in HIV-associated glomerulosclerosis and idiopathic focal segmental glomerulosclerosis. These findings consist largely of immunoglobulin M and complement C3 deposited in a segmental granular pattern in the mesangium and capillaries. The same deposits also occur in 30% of patients with AIDS without renal disease [134,163,167].

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