Figure 734

HIV proteins in glomerulosclerosis. HIV-associated glomerulosclero-sis has been viewed as a complication that occurs either as a direct cellular effect of HIV infection or HIV gene products in the kidney, as an indirect effect of the dysregulated cytokine milieu existing in patients with acquired immunodeficiency syndrome, or both. Studies involving reciprocal transplantation of kidneys between normal and mice transgenic of noninfectious HIV clearly show that the patho-genesis of HIV-glomerulosclerosis is intrinsic to the kidney [176]. In these studies, HIV-glomerulosclerosis developed in kidneys of trans-genic mice transplanted into nontransgenic littermates, whereas kidneys from normal mice remained disease-free when transplanted into HIV-transgenic mice [176]. These findings suggest that HIV gene proteins, rather than infective HIV, may induce the nephropathy either through direct effects on target cells or indirectly through the release of cytokines and growth factors.

0 0

Post a comment