Figure 738

Angiotensin-converting enzyme (ACE) inhibitors and angiotensin II type I receptor antagonists. Angiotensin-converting enzyme inhibitors and angiotensin II type I receptor antagonists lower blood pressure by decreasing peripheral vascular resistance; there is usually little change in heart rate or cardiac output [6,9,15].

Mechanisms proposed for the observed decrease in peripheral resistance are shown [15]. Sites of pharmacologic blockade in the renin angiotensin system: 1) renin inhibitors, 2) ACE inhibitors, 3) angiotensin II type I receptor antagonists, 4) angiotensin II type II receptor antagonists.

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