Figure

A-C. Diuretics: benzothiadiazides and related agents, loop diuretics, and potassium-sparing agents. A partial list of benzothiadiazides and their related agents is given [6]. With the exception of inda-pamide and metolazone, their dose-response curves are shallow; they should not be used when the glomerular filtration rate is less than 30 mL/min/1.73 m2. The second group listed is loop diuretics. Because of their steep dose-response curves and natriuretic potency, they are especially useful when the glomerular filtration rate is less than 30 mL/min/1.73 m2. The third group is the potassium-sparing diuretics. The major therapeutic use of these drugs is to attenuate the loss of potassium induced by the other diuretics.

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