Renal cholesterol content modulates renal tubular phosphate reabsorption. In aged rats versus young rats and rats fed a diet high in phosphate versus a diet low in phosphate, an inverse correlation exists between the brush border membrane (BBM) cholesterol content (A) and Na-P( cotransport activity (B). Studies in isolated BBM vesicles and recent studies in opossum kidney cells grown in culture indicate that direct alterations in cholesterol content per se modulate Na-Pj cotransport activity [15]. CON—controls.

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