Figure 83

Cytokines implicated in perpetuating granulomas. Cytokines released by the infiltrating mononuclear cells and T-cell lymphocytes initiate the cascade of inflammatory reaction that results in subsequent formation of the noncaseating granulomas that characterize sarcoidosis. It is the loss of the otherwise balanced ability of cytokines to modulate the inflammatory response that accounts for the progression of the initial inflammatory reaction to granulomatous formation, and ultimately to the more detrimental process of fibrosis. Macrophages are critical in inducing fibroblasts to proliferate and deposit fibronectin and collagen in the extracellular matrix.

0 0

Post a comment