Figure 834

Consequences of urinary tract obstruction for the developing kidney in animals. The effects of urinary tract obstruction on the developing kidney depend on the time of onset, location, and degree of obstruction. Ureteral obstruction during early pregnancy results in disorganization of the renal parenchyma (dysplasia) and a reduction in the number of nephrons. Partial or complete ureteral obstruction in neonates causes vasoconstriction, glomerular hypoperfusion, impaired ipsilateral renal growth, and interstitial fibrosis. The degree of impairment of the ipsilateral kidney, in the case of partial unilateral ureteral obstruction, and of compensatory hypertrophy of the contralateral kidney, in the case of partial or complete unilateral ureteral obstruction, is inversely related to the age of the animal at the time of obstruction. The older the animal, the less the impairment of the ipsilat-eral kidney and the less the compensatory growth of the contralateral kidney. In addition, the recovery of renal function after relief of urinary tract obstruction also decreases with the age of the animal [45].

t PGE2, t PGI2 tAngiotensin II

t PGE2, t PGI2 tAngiotensin II

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